Dr. J. Jeya Maheshwari

Qualification M.Sc., Ph.D.
Designation Scientist
Proteomics
Aravind Medical Research Foundation
e-mail id jeya@aravind.org

Introduction

Dr. J. Jeya Maheshwari completed her Bachelor of Science, Master of Science and Master of Philosophy in Biochemistry from Madras University. After a brief work experience in the corporate sector, she joined Madurai Kamaraj University for the Post-M.Sc Advanced Diploma in Bioinformatics in 2002. Later, she pursued her Ph.D. under the supervision of Prof. K. Dharmalingam in the Genetic Engineering Research Unit availing ICMR fellowship. During her Ph.D. tenure, she worked extensively in characterizing the functional and structural aspects of a small heat shock protein (sHsp18) from Mycobacterium leprae, the causative agent of leprosy. She made significant contributions in deciphering the role of this sHsp18 in the infection process. She received her Ph.D. from Madurai Kamaraj University in 2011. She was awarded the RA fellowship from Department of Biotechnology, Government of India to carry out her post-doctoral work in fungal keratitis at the Proteomics Department in Aravind Medical Research Foundation.

Research & Publications

Dr. Jeya Maheshwari is currently involved in the research on three major eye diseases fungal keratitis, diabetic retinopathy and glaucoma with a focus on understanding the pathogenesis underlying these diseases using proteomics approaches. These studies are aimed towards the identification and validation of protein biomarkers with diagnostic and/or prognostic value.

Peer-Reviewed Journals
  1. Wong SSW, Venugopalan LP, Beaussart A, Karnam A, Mohammed MRS, Jayapal JM, Bretagne S, Bayry J, Prajna L, Kuppamuthu D, Latgé JP, Aimanianda V. Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two Aspergillus, Aspergillus fumigatus and A. flavus. Front Cell Infect Microbiol. 2021 Feb 25;11:643312.
  2. Wong SSW, Daniel I, Gangneux JP, Jayapal JM, Guegan H, Dellière S, Lalitha P, Shende R, Madan T, Bayry J, Guijarro JI, Kuppamuthu D, Aimanianda V. Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus. Infect Immun. 2020 Aug 19;88(9):e00212-20.
  3. Shait Mohammed MR, Krishnan S, Amrathlal RS, Jayapal JM, Namperumalsamy VP,Prajna L, Kuppamuthu D. Local Activation of the Alternative Pathway ofComplement System in Mycotic Keratitis Patient Tear. Front Cell InfectMicrobiol. 2020 May 6;10:205.
  4. Rathinam S, Daniel I, Kuppamuthu D, Jayapal JM. Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients. Ocul Immunol Inflamm. 2019 Nov 20:1-8. [Epub]
  5. Parthiban N, Sampath NL, JeyaMaheshwari J, Prajna NV, Lalitha P, Dharmalingam Quantitative profiling of tear proteome reveals down regulation of zinc alpha-2 glycoprotein in Aspergillus flavus keratitis patients. Exp Eye Res. 2019 Sep;186:107700.
  6. Shait Mohammed MR, Balamurgan MK, Amrathlal RS, Kannan P, Jayapal JM, Namperumalsamy VP, Prajna L, Dharmalingam K. Dataset for the spore surface proteome and hydrophobin A/RodA proteoforms of A.flavus. Data Brief. 2019 Mar 15;23:103817.
  7. Shait Mohammed MR, Balamurugan M, Amrathlal RS, Kannan P, Jayapal JM, Namperumalsamy VP, Prajna L, Kuppamuthu D. Identification of the proteoforms of surface localized Rod A of Aspergillus flavus and determination of the mechanism of proteoform generation. J Proteomics. 2019 Feb 20;193:62-70.
  8. Kandhavelu J, Demonte NL, Namperumalsamy VP, Prajna L, Thangavel C, Jayapal JM, Kuppamuthu D. Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection. J Proteomics. 2017 Jan 30;152:13-21.
  9. Kandhavelu J, Demonte NL, Namperumalsamy VP, Prajna L, Thangavel C, Jayapal JM, Kuppamuthu D. Data set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection. Data Brief. 2016 Nov 9;9:888-894.
  10. Selvam RM, Nithya R, Devi PN, Shree RS, Nila MV, Demonte NL, Thangavel C, Maheshwari JJ, Lalitha P, Prajna NV, Dharmalingam K. Exoproteome of Aspergillus flavus corneal isolates and saprophytes: identification of proteoforms of an oversecreted alkaline protease. J Proteomics. 2015 Feb 6;115:23-35.
  11. Muthu Selvam R, Nithya R, Narmatha Devi P, Bhuvana Shree RS, Valar Nila M, Demonte NL, Thangavel C, Jeya Maheshwari J, Lalitha P, Venkatesh Prajna N, Dharmalingam K. Data set for the mass spectrometry based exoproteome analysis of Aspergillus flavus isolates. Data Brief. 2014 Dec 15;2:42-7.