Dr. S.R. Krishnadas

Qualification DO, DNB
Designation Member, Aravind Medical Research Foundation
Director – HRD, Aravind Eye Care System
Director – Senior Medical Consultant, Glaucoma Services
Location Aravind Eye Hospital, Madurai

Introduction

Dr R Krishnadas has been serving Aravind Eye Hospitals in various capacities for the past quarter of a century. He has been an attendant physician at the Glaucoma services at Madurai, Head of the Clinical Services, Chief Medical Officer and currently serves as the Director of Human Resources Department.

Dr. Krishnadas has been a visiting Fellow in various eye departments of major hospitals in the US including the Wilmer Ophthalmological Institute of John Hopkins University, Wilmer Eye Institute and the Ophthalmology Department of Bascom Palmer Eye Institute.   He has been actively involved in patient care, training and teaching of Post Graduates and Ophthalmologists in the specialty of Glaucoma.  He has been an invited faculty at the Glaucoma Society of India, All India Ophthalmological Society, and the Tamil Nadu, Orissa, West Bengal, Madhya Pradesh and Jharkhand Ophthalmological Societies.

Research & Publications

Dr. Krishna Das has also been part of several research initiatives conducted in glaucoma at Aravind including the study of epidemiology of glaucoma in South India, and role of genetics and proteomic studies in glaucoma and is collaborating to evolve automated detection solutions for early diagnosis of glaucoma in the community. He has co-authored close to 40 peer reviewed publications.

  1. Krishnadas R. Commentary: Blindness from glaucoma associated with steroid abuse in children. Indian J Ophthalmol. 2019;67:1655-1656.
  2. George V Puthuran, Palmberg P, Hiruni KW, Krishnadas R, Robin A. Intermediate-Term Outcomes of an Affordable Aqueous Drainage Implant in Adults with Refractory Glaucoma. Ophthalmology Glaucoma. 2019;2:258-266.
  3. Kantipuly A, Manju Pillai R, Sujani S, Rakhee K, Ganesh V Raman, Krishnadas R, Robin AL, Ehrlich JR. Caregiver burden in primary congenital glaucoma. Am J Ophthalmol. 2019;205:106-114.
  4. Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu X, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z. Mutant RAMP2 causes primary open-angle  glaucoma via the CRLR-cAMP axis. Genet Med. 2019 Apr 19. [Epub]
  5. Krishnadas R. Current management options in primary angle closure disease. Indian J Ophthalmol. 2019;67:321-3.
  6. Sharmila R, Sujani Shroff, Sangeeta VP, Mohammed Sithiq U, Ashok Vardhan, Krishnadas SR. Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C. Indian J Ophthalmol. 2019;67:95-100.
  7. Ashwinbalaji S, Senthilkumari S, Gowripriya C, Krishnadas S, Gabelt BAT, Kaufman PL, Muthukkaruppan V. SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes. Sci Rep. 2018;8:15472.
  8. Nongpiur ME, Cheng, C Y, Roopam, D, Vijayan, S, Baskaran, M, Khor, CC, Allen, J, Kavitha, S, Venkatesh, R, Goh, D, Husain, R, Boey, P Y, Quek, D, Ho, C L, Wong, T T, Perera, S, Wong, T Y, Krishnadas R, Sundaresan, P, Aung, T, Vithana, E N. Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. Ophthalmology. 2018;125:664-670.
  9. Manju Pillai R, Hasini, P P, Ahuja Ashish, Krishnadas R. A Rare Case of Overlapping Sturge-Weber Syndrome and Klippel-Trenaunay Syndrome Associated with Bilateral Refractory Childhood Glaucoma. Indian J Ophthalmol. 2017;65:623-625.
  10. Mohd Hussain Shah, Tabanera, N, Krishnadas R, Manju Pillai, R, Paola, B, Sundaresan, P. Identification and Characterization of Variants and a Novel 4 bp Deletion in the Regulatory Region of SIX6, a Risk Factor for Primary Open-Angle Glaucoma. Mol Genet Genom Med. 2017;5:323-335.
  11. Mohideen Abdul Kader, Namburi, P, Sarika, R, Ramakrishnan, R, Krishnadas R, Roos, B R, Sundaresan, P, Robin, A L, Fingert, J H. Clinical and Genetic Characterization of a Large Primary Open Angle Glaucoma Pedigree. Ophthalmic Genet. 2017;38:222-225.
  12. Indra Durai, Mrunali, M D, Prem Anand, C, Ganesh, V Raman, Krishnadas R. Bilateral, Simultaneous, Acute Angle Closure Glaucoma in Pseudophakic Induced by Chlorthalidone, V. Case Rep Med. 2016;2016:3713818.
  13. Khor CC, Do, T, Jia, H, Nakano, M, George, R, Abu-Amero, K, Roopam Duvesh, Chen, L J, Venkatesh, R, Krishnadas R, Kavitha, S. Genome-Wide Association Study Identifies Five New Susceptibility Loci for Primary Angle Closure Glaucoma. Nat Genet. 2016;48:556-562.
  14. Lipi Chakrabarty, Joshi, G D, Chakravarty, A, Ganesh, V Raman, Krishnadas R, Sivaswamy, J. Automated Detection of Glaucoma from Topographic Features of the Optic Nerve Head in Color Fundus Photographs. J Glaucoma. 2016;25:590-7.
  15. Senthilkumari S, Neethu, M, Shanthi, R, Krishnadas R, Muthukkaruppan, V R. Identification of Glaucomatous Optic Nerve Head Changes in Indian Donor Eyes without Clinical History. Indian J Ophthalmol. 2015;63:600-605.
  16. Sivaswamy J, Krishnadas R, Chakravarty, Arunava, Joshi, Gopal Datt, Ujjwal, Syed, Tabish Abbas.A Comprehensive Retinal Image Dataset for the Assessment of Glaucoma from the Optic Nerve Head Analysis. JSM Biomed Imaging Data Pap. 2015;2:1-7.
  17. Dubey SK, Hejtmancik, J F, Krishnadas R, Sharmila, R, Haripriya, Aravind, Sundaresan, P. Evaluation of Genetic Polymorphisms in Clusterin and Tumor Necrosis Factor-Alpha Genes in South Indian Individuals with Pseudoexfoliation Syndrome. Curr Eye Res. 2015;40:1218-1224.
  18. Sharmila R, Nidhi Gupta, Vijayakumar, B, Kumaragurupari, R, Krishnadas R. Screening First Degree Relatives of Persons with Primary Open Angle Glaucoma in India. J Curr Glauocma Practice. 2014;8 :107-112.
  19. Neethirajan G, Krishnadas R, Vijayalakshmi, P, Shashikant Shetty, Sundaresan, P. PAX6 mRNA Transcript Analysis in Various Ocular, Non-Ocular Tissues. Adv Ophthalmol Vis Syst. 2014;1:00026.
  20. Dubey SK, Hejtmancik, J F, Krishnadas R, Sharmila, R, Haripriya, Aravind, Sundaresan, P. Lysyl Oxidase-Like 1 Gene in the Reversal of Promoter Risk Allele in Pseudoexfoliation Syndrome. JAMA Ophthalmol. 2014;132:949-955.
  21. Maya N, Krishnadas R, Jeganathan, J. Comparison of Central Corneal Thickness of Primary Open Angle Glaucoma Patients with Normal Controls in South India. Oman J Ophthalmol. 2013;6:33-36.
  22. Joshi GD, Sivaswamy, J, Krishnadas R. Depth Discontinuity-Based Cup Segment. IEEE Trans Biomed Eng. 2012;59:1523-1531.
  23. Krishnadas R, Ramakrishnan, R. A Study of Initial Therapy for Glaucoma in Southern India: India glaucoma outcomes and treatment (INGOT) study. Ophthalmic Epidemiol. 2012;19:149-158.
  24. Suganthalakshmi B, Krishnadas R, Jiao, X, Hejtmancik, J F, Sundaresan, P. Evaluation of SNPs on Chromosome 2p with Primary Open-Angle Glaucoma in the South Indian Cohort. Invest. Ophthalmol. Vis. Sci. 2012;53:1861-4.
  25. Rangachari K, Jeyalaxmi, J, Pandaranayaka, Eswari, Prasanthi, N, Sundaresan, P, Krishnadas R, Krishnaswamy, S.Significance of G-X-W Motif in the Myocilin Olfactomedin Domain. J Ocul Biol Dis Infor. 2011;4:154-158.
  26. Prateek Agarwal, Gopal Gaurav Devendra, Shashikant Shetty, Krishnadas R, Vijaylakshmi, P, Muralidhar, R. Central Corneal Thickness in Congenital Aniridia and its Role in Glaucoma in an Indian Population. Asian J Ophthalmol. 2011;12:189-191
  27. Hennessy AL, Katz, J, Ramakrishnan, R, Krishnadas R, Thulasiraj, RD, Tielsch, J M, Robin, Alan L. The Utility of Relative Afferent Pupillary Defect as a Screening Tool for Glaucoma: prospective examination of a large population-based study in a south Indian population. Br J Ophthalmol. 2011;95:1203-1206.
  28. Gopal Datt Joshi, Jayanthi Sivaswamy, Krishnadas R. Optic Disk and Cup Segementation from Monocular Color Retinal Images for Glaucoma Assessment. IEEE Trans Med Imaging. 2011;30:1192-1205.
  29. Rangachari K, Dhivya, M, Eswari Pandaranayaka, P J, Prasanthi, N, Sundaresan, P, Krishnadas R, Krishnaswamy, S. Glaucoma Database. Bioinformation. 2011;5:398-399.
  30. Eswari Pandaranayaka, P J Prasanthi, N, Kannabiran, N, Rangachari, K, Dhivya, M, Krishnadas R, Sundaresan, P, Krishnaswamy, S. Polymorphisms in an Intronic Region of the Myocilin Gene Associated with Primary Open-Angle Glaucoma – A Possible Role for Alternate Splicing. Mol. Vis. 2010;16:2891-2902.
  31. Rathinam SR, Krishnadas R, Ramakrishnan, R, Thulasiraj, RD, Tielsch, J M, Katz, J, Robin, A L, Kempen, J H, Aravind Comprehensive Eye Survey Research Group. Population-Based Prevalence of Uveitis in Southern India. Br J Ophthalmol. 2011;95:463-7.
  32. Karan Kumar, Krishnadas R. Update on Medical Treatment of Congenital Glaucomas. Highlights of Ophthalmology. 2009
  33. Nguyen HJ, Krishnadas R. Intraobserver Variability of Confocal Scanning Laser Ophthalmology with and without Stereo Photographs. Br J Ophthalmol. 2009;93:1552-1553.
  34. Neethirajan G, Solomon, Abraham, Krishnadas R, Vijayalakshmi, P, Sundaresan, P.Genotype, Phenotype Association in Indian Congenital Aniridia. Indian Journal of Pediatrics. 2009;76:513-517.
  35. Nitin Deshpande, Lalitha, Prajna, Krishnadas R, Jitendra Jethani, Manju Pillai, R, Robin, Alan, Karthik.Helicobacter Pylori IgG Antibodies in Aqueous Humor and Serum of Subjects with Primary Open Angle and Pseudo-Exfoliation Glaucoma in a South Indian Population. J Glaucoma. 2008;17:605-610.
  36. Eswari Pandaranayaka, P J Kanagavalli, Janakaraj, Krishnadas R, Sundaresan, P, Krishnasamy, S.Over Expression and Purification of Recombinant Human Myocilin. World J Microbiol Biotechnol. 2008;24:903.
  37. Shukla D, Vidhya, S, Noela Marie Prasad, Mahalakshmi, Rajendran, Chandramohan, K, Krishnadas R. Evaluation of Patients age as a Risk for Intraocular Pressure Elevation after intravitreal Traimcinolone. Am. J. Ophthalmol. 2007;144:453-454.
  38. Hewitt AW, Samples, John R, Allingham, R Rand, Jarvela, Irma, Kitsos, George, Krishnadas R, Richards, Julia E, Lichter, Paul R, Petersen, Michael B, Sundaresan, P, Wiggs, Janey L, Mackey, David A, Wirtz, Mary K. Investigation of Founder Effects for the Thr377Met Myocilin Mutation in Glaucoma Families from Differing Ethnic Backgrounds. Mol. Vis. 2007;13:487-492.
  39. Rakhi Mehta, George, V Puthuran, Krishnadas R, Mahalakshmi, Rajendran. Efficacy of Transsleral Diode Laser Cyclophotocoagulation for Refractory in a South Indian Population. Asian J Ophthalmol. 2006;8:232-236.
  40. Nitin Deshpande, Shashikant Shetty, Krishnadas R. Pupillary-Iris-Lens Membrane with Goniodysgenesis: a case report. Indian J Ophthalmol. 2006;54:275-276.
  41. Neethirajan G, Nallathambi, J, Krishnadas R, Vijayalakshmi, P, Shashikant Shetty, Collinson, Jon Martin, Sundaresan, P. Identification of Novel Mutant PAX6 Alleles in Indian Cases of Familial Aniridia. BMC Ophthalmol. 2006;6.
  42. Praveen K Nirmalan, Tielsch, James M, Katz, Joanne, Thulasiraj, R D, Krishnadas R, Ramakrishnan, R, Robin, Alan L. Relationsip between Vision Impairment and Eye Disease to Vision-Specific Quality of Life and Function in Rural India: the Aravind comprehensive eye survey. Invest. Ophthalmol. Vis. Sci. 2005;46:2308-2312.
  43. Mansberger SL, Johnson, Chris A, Cioffi, George A, Choi, Dongseok, Krishnadas R, Srinivasan, M, Balamurugan, V, Usha, Kim R, Smith, Scott D, Wilkins, John H, Gritz, David C. Predictive Value of Frequency Doubling Technology Perimetry for Detecting Glaucoma in a Developing Country. J Glaucoma. 2005;14:128-134.
  44. Robin AL, Praveen, K Nirmalan, Krishnadas R, Ramakrishnan, R, Katz, Joanne, Tielsch, James, Thulasiraj, R D, Friedman, David S. The Utilization of Eye Care Services by Persons with Glaucoma in Rural South India. Trans Am Ophthalmol Soc. 2004;102:47-55.
  45. Praveen K Nirmalan, Katz, Joanne, Robin, Alan L, Ramakrishnan, R, Krishnadas R, Thulasiraj, R D, Tielsch, James M. Female Reproductive Factors and Eye Disease in a Rural South Indian Population: the Aravind comprehensive eye survey. Invest. Ophthalmol. Vis. Sci. 2004;45:4273-4276.
  46. Neethirajan G, Collinson, J Martin, Krishnadas R, Vijayalakshmi, P, Shashikant Shetty, Reena, Chandrashekhar, Sundaresan, P. De Novo Deletions in the Paired Domain of PAX6 in South Indian Aniridic Patients. J Human Genet. 2004;49:647-649.
  47. Neethirajan G, Krishnadas R, Vijayalakshmi, P, Shashikant Shetty, Sundaresan, P.PAX6 Gene Variations Associated with Aniridia in South India. BMC Med. Genet. 2004;5:9-15.
  48. Praveen K Nirmalan, Katz, J, Robin, A L, Krishnadas R, Ramakrishnan, R, Thulasiraj, R D, Tielsch, J. Utilisation of Eye Care Services in Rural South India: the Aravind comprehensive eye survey. Br J Ophthalmol. 2004;88:1237-1241.
  49. Kanagavalli J, Pandaranayaka, Eswari, Krishnadas R, Krishnaswamy, Sankaran, Sundaresan, P. Current Ophthalmology: A Review of Genetic and Structural Understanding of the Role of Myocilin in Primary Open Angle Glaucoma. Indian J Ophthalmol. 2004;52:271-280.
  50. Praveen K Nirmalan, Katz, Joanne, Tielsch, James M, Robin, Alan L, Thulasiraj, R D, Krishnadas R, Ramakrishnan, R .Ocular Trauma in a Rural South Indian Population: the Aravind comprehensive eye survey. Ophthalmology. 2004;111:1778-1781.
  51. Praveen K Nirmalan, Robin, A L, Katz, J, Tielsch, J M, Thulasiraj, RD, Krishnadas R, Ramakrishnan, R. Risk Factors for Age-Related Cataract in a Rural Population of Southern India: the Aravind Comprehensive eye study. Br J Ophthalmol. 2004;88:989-994.
  52. Praveen K Nirmalan, Katz, Joanne, Robin, Alan L, Tielsch, James M, Namperumalsamy, P, Kim, R, Narendran, V, Ramakrishnan, R, Krishnadas R, Thulasiraj, R D, Suan, Eric. Prevalence of Vitreoretinal Disorders in a Rural Population of Southern India: the Aravind comprehensive eye study. Arch Ophthal. 2004;122:581-586.
  53. Raman Mehta, Krishnadas R. Glaucoma Associated with Trauma. Eye Care. 2003:36-43.
  54. Kanagavalli J, Krishnadas R, Pandaranayaka, Eswari, Krishnaswamy, Sankaran, Sundaresan, P. Evaluation and Understanding of Myocilin Mutations in India Primary Open Angle Glaucoma Patients. Mol. Vis. 2003;9:606-614.
  55. Neethirajan G, Hanson, Isabel M, Krishnadas R, Vijayalakshmi, P, Anupkumar, Kesavan, Sundaresan, P. A Novel PAX6 Gene Mutation in an Indian Aniridia Patient. Mol. Vis. 2003;9:205-209.
  56. Praveen K Nirmalan, Krishnadas R, Ramakrishnan, R, Thulasiraj, R D, Katz, Joanne, Tielsch, James M, Robin, Alan L. Lens Opacities in a Rural Population of Southern India: the Aravind comprehensive eye study. Invest. Ophthalmol. Vis. Sci. 2003;44:4639-4643.
  57. Thulasiraj RD, Praveen, K Nirmalan, Ramakrishnan, R, Krishnadas R, Manimekalai, T K, Baburajan, N P, Katz, Joanne, Tielsch, James M, Robin, Alan L.Blindness and Vision Impairment in a Rural South Indian Population: the aravind comprehensive eye survey. Ophthalmology. 2003;110:1491-1498.
  58. Ramakrishnan R, Praveen, K Nirmalan, Krishnadas R, Thulasiraj, R D, Tielsch, James M, Katz, Joanne, Friedman, David S, Robin, Alan L. Glaucoma in a Rural Population of Southern India: the Aravind comprehensive eye survey. Ophthalmology. 2003;110:1484-1490.
  59. Krishnadas R, Praveen, K Nirmalan, Ramakrishnan, R, Thulasiraj, R D, Katz, Joanne, Tielsch, James M, Friedman, David S, Robin, Alan L. Pseudoexfoliation in a Rural Population of Southern India: the Aravind comprehensive eye survey. Am. J. Ophthalmol. 2003;135:830-837.
  60. Dan JA Honavar, Santosh G, Belyea, David A, Mandal, Anil K, Garudadri, Chandrasekhar, Levy, Brian, Ramakrishnan, R, Krishnadas R, Lieberman, Marc F, Stamper, Robert L, Yaron, Arieh. Enzymatic Sclerostomy: pilot human study. Arch Ophthal. 2002;120:548-553.
  61. Arup Chakrabarti, Seema Singh, Krishnadas R. Phacoemulsification in White Cataracts. J Cataract Refract Surg. 2000;26:1041-1047.
  62. Arup Chakrabarti, Krishnadas R, Meena Chakrabarti. Ab Externo 4-Point Scleral Fixation of Posterior Chamber Intraocular Lenses. J Cataract Refract Surg. 1999;25:420-426.
  63. Robin AL, Ramakrishnan, R, Krishnadas R, Smith, Scott D, Katz, Joanne D, Selvaraj, S, Skuta, Gregory L, Bhatnagar, Rohit. A Long-Term Dose-Response Study of Mitomycin in Glaucoma Filtration Surgery. Arch Ophthal. 1997;115:969-974.
  64. Prajna NV, Ramakrishnan, R, Krishnadas R, Manoharan, N. Lens Induced Glaucomas – Visual Results and Risk Factors for Final Visual Acuity. Indian J Ophthalmol. 1996;44:149-155.
  65. Ramakrishnan R, Michon, John, Robin, Alan L, Krishnadas R. Safety and Efficacy of Mitomycin C Trabeculectomy in Southern India: a short-term pilot study. Ophthalmology. 1993;100:1619-1623.

Awards & Recognition

  • Oration Awards from the Orissa Ophthalmological Society, Jharkhand Ophthalmological Society, and the Coimbatore Chapter of the Indian Medical Association.
  • Lifetime Achievement Award in recognition of his contribution to patient care, teaching and research in Glaucoma by the Silver Jubilee Scientific Committee of the National Institute of Ophthalmology, Pune.
  • He has made oral presentations in Asia ARVO, and the American Academy of Ophthalmology Annual Conferences as well as in the International Society of Geographic Epidemiology and Ophthalmology.