Dr. Bharani’s specializes in the analysis of next-generation sequencing data, machine learning techniques and the study of microRNA (miRNA) dynamics in ocular health. His research interests focus on the role of microRNAs (miRNAs) in ocular pathogenesis, particularly in conditions like keratitis and ocular tuberculosis, investigating how their dysregulation impacts eye health. Additionally, he examines the interplay between miRNAs, genes, proteins, and the microbiome to uncover diagnostic and prognostic markers for the management of eye diseases.

MiRNAs:

• Swathi Chadalawada, SR.Rathinam, Prajna Lalitha, Naresh Babu Kannan, Bharanidharan Devarajan “ Detection of microRNAS expression signatures in vitreous humor of intraocular tuberculosis” Molecular Biology Reports Oct 2023
• Kalaimani, Lavanya, Bharanidharan Devarajan, Venkatesh Prajna Namperumalsamy, Muthukkaruppan Veerappan, Julie T. Daniels, and Gowri Priya Chidambaranathan. “Hsa-miR-143-3p inhibits Wnt-β-catenin and MAPK signaling in human corneal epithelial stem cells.” Scientific reports 12, no. 1 (2022): 1-11.
• Lavanya Kalaimani, Bharanidharan Devarajan, Venkatesh Prajna Namperumalsamy, Muthukkaruppan Veerappan, Julie T Daniels, Gowri Priya Chidambaranathan, “Hsa-miR-150-5p inhibits Wnt-β-catenin signaling in human corneal epithelial stem cells” Molecular Vision 2022; 28:178-191
• Chadalawada, Swathi, Kandasamy Kathirvel, Prajna Lalitha, S. R. Rathinam, and Bharanidharan Devarajan. “Dysregulated expression of microRNAs in aqueous humor from intraocular tuberculosis patients.” Molecular Biology Reports (2021): 1-11.
• Boomiraj H, Mohankumar V, Lalitha P, Devarajan B. Human corneal microRNA expression profile in fungal keratitis. Investigative ophthalmology & visual science. 2015;56(13):7939-46.

Genomics and Informatics:

• Kader, Mohideen Abdul*, Devarajan, Bharanidharan*, Vijayan, Saravanan, Ramakrishnan, Rengappa, Sundaresan, Periasamy, Uduman, Mohammed Sithiq, Krishnadas, Subbiah R, Kuppamuthu, Dharmalingam Kader (2023). “Myocilin Mutation N480K Leads to Early Onset Juvenile and Adult-onset Primary Open Angle Glaucoma in Six Generations of a Family.” Journal of glaucoma: 10.1097
• Kumaran, M. and Bharanidharan Devarajan (2023). “eyeVarP: a computational framework for the identification of pathogenic variants specific to eye disease.” Genetics in Medicine: 100862.
• Subramanian; B. Devarajan, Identification of dysregulated pathways and key genes in human retinal angiogenesis using microarray metadata, Gene Reports, 2022;26:101434.
• Kathirvel, Kandasamy, O. Rudhra, Siva Ganesa Karthikeyan Rajapandian, Namperumalsamy Venkatesh Prajna, Prajna Lalitha, and Bharanidharan Devarajan. “Characterization of antibiotic resistance and virulence genes of ocular methicillin-resistant Staphylococcus aureus strains through complete genome analysis.” Experimental eye research 212 (2021): 108764.
• Kandasamy K, Thirumalmuthu K, Prajna NV, Lalitha P, Mohankumar V, Devarajan B. Comparative genomics of ocular Pseudomonas aeruginosa strains from keratitis patients with different clinical outcomes. Genomics. 2020;112(6):4769-76.
• Kumaran M, Subramanian U, Devarajan B. Performance assessment of variant calling pipelines using human whole exome sequencing and simulated data. BMC bioinformatics. 2019;20(1):1-11.
• Khedekar A, Devarajan B, Ramasamy K, Muthukkaruppan V, Kim U. Smartphone-based application improves the detection of retinoblastoma. Eye. 2019;33(6):896-901.
• Devarajan B, Prakash L, Kannan TR, Abraham AA, Kim U, Muthukkaruppan V, et al. Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma. BMC cancer. 2015;15(1):1-10.

• Young Scientist Fellowship (2015-2018) by SERB, Department of science and Technology, India.
• Member of the Association for Research in Vision and Ophthalmology (ARVO), USA
• ARVO publication award (2015)
• Recognized guide in Madurai Kamaraj University (MKU) to guide Ph.D registrants in Biomedical Sciences.
• Recognized guide in Alagappa University to guide Ph.D registrants in Biotechnology.
• Recognized guide in SASTRA University to guide Ph. D registrants in Chemistry and Biotechnology.
• Best Post Presentation Award (2004) From “International Symposium on Recent Trends in Macromolecular Structure and Function”, Department of crystallography and Biophysics, University of Madras, Chennai, India
• Research Assistant Fellowship (2001-2007) by Council of Scientific and Industrial Research, India to participate in the development of a comprehensive bioinformatics software package “BioSuite”