Dr. O.G. Ramprasad

Qualification M.Sc., Ph.D.
Designation Scientist
Aravind Medical Research Foundation
e-mail id ramprasad@aravind.org

Dr. O. G. Ramprasad received his Masters in Five-year Integrated Life Sciences (Microbiology specialization) from Bharathidasan University, Tiruchirappalli in 2000. He obtained his PhD from the Centre for Cellular and Molecular Biology (CCMB) at Hyderabad in 2008 for his studies related to the signalling mechanisms of membrane cholesterol and other associated lipids during cell migration.

Dr. Ramprasad did his postdoctoral studies in melanoma and breast cancer at  Centre Pluridisciplinaire d’Oncologie, University of Lausanne, Switzerland during the period 2009-2011 and later worked as a Research Associate at the Indo-American Cancer Centre at Hyderabad during the period 2012- 2014 in the field of oral cancer.

Ramprasad’s research interests include regulation of microRNAs during the progression of diabetic retinopathy, development of novel cross-linking agents of the cornea to prevent the progression of keratoconus and signalling mechanisms in the corneal epithelium during fungal keratitis infection.

Current research areas:

Functional analysis of circulating microRNAs and their regulatory role in Diabetic retinopathy

The objective of this study is to reveal disease specific miRNAs from serum of Proliferative Diabetic Retinopathy, Non-proliferative Diabetic retinopathy and Diabetes mellitus patients and compare it with serum samples of control healthy patients. Towards this objective, we have identified microRNAs 27b, 320a, 181a and 451a as significantly differentiated miRNAs in the progression of different stages of diabetic retinopathy. We have identified the differential expression of thrombospondin-1, the target protein of miRNAs 27b and 320a in serum samples of Diabetic retinopathy patients. These set of miRNAs have the potential to be characterized as predictive biomarkers for diabetic retinopathy progression.

Novel Chemical Crosslinking of the Cornea for Treatment of Keratoconus

The major objective of this project is the development of a novel chemical cross-linker for the treatment of keratoconus. The novel chemical cross-linker aims to overcome the removal of epithelium and the pain associated with the patients while undergoing conventional UV-Riboflavin cross-linking treatment. This is a collaborative project between AMRF, University of Liverpool and the Aurolab. The novel chemical cross-linker has exhibited negligible cytotoxicity to the porcine and human corneas. It penetrates to around 200 mm into the stroma of the cornea to induce significant increase in the stiffness of the cornea without altering the corneal morphology. The mechanism of action of the novel cross-linker is going to be analysed in a separate study. The cross-linker formulation has shown great promise for further trials and formulation. The ultimate clinical formulation will be done by Aurolab.

  • Received Early career research award from SERB, Govt. of India for research on diabetic retinopathy.
  • Travel and registration award from EPSRC, UK to attend the ASIA-ARVO conference at Brisbane, Australia, Feb 4-8, 2017.
  • Funding from Engineering and Physical Science Research Council, UK for the collaborative project on keratoconus with the University of Liverpool, UK.
  • Travel award from the Department of Biotechnology, Govt. of India and American Society for Cell Biology to attend the 2005 ASCB summer meeting on “Systems Integration in Directed Cell Motility” at Seattle, USA.
  • Awarded a travelling fellowship in 2002 by the Indo-French Centre for the Promotion of Advanced Research, New Delhi to work in the collaborator’s lab of Dr. Jean Paul Thiery at Institut Curie, Paris.
  • Awarded the competitive Junior and Senior Research Fellowships for PhD by University Grants Commission, Govt. of India through Joint CSIR-UGC NET Examination in July 2000.
  • Administrative Responsibility: Member Secretary, Institutional Committee for Stem Cell Research, Aravind Medical Research Foundation.