Dr. S. Senthil Kumari

Qualification M.Pharm., Ph.D.
Designation Scientist
Ocular Pharmacology
Aravind Medical Research Foundation
e-mail id ss_kumari@aravind.org

Introduction

Dr. Senthilkumari has received her Bachelor degree in Pharmaceutical Sciences (B. Pharm) from the TN Dr. M. G. R. Medical University, Chennai in 1999 and her Master degree (M. Pharm) in Pharmaceutical Chemistry from Birla Institute of Technology, Mesra, Ranchi in 2001. She has received her Ph.D. in Ocular Pharmacology from Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi in 2008. She has joined Aravind Medical Research Foundation in August 2008.

Research & Publications

Dr. Kumari’s research interest is on understanding the molecular mechanism(s) involved in the pathogenesis and identifying drug targets for the “silent-sight killer – the Glaucoma especially POAG and steroid-induced glaucoma”.

Peer-Reviewed Journals
  1. Ravinarayanan Haribalaganesh, Chidambaranathan Gowri Priya, Rajendrababu Sharmila, Subbaiah Krishnadas, VeerappanMuthukkaruppan, Colin E. Willoughby,  Srinivasan Senthilkumari “Assessment of differential intraocular pressure response to dexamethasone treatment in perfusion cultured Indian cadaveric eyes” Scientific Reports | (2021) 11:605
  2. Hazarika M, Prajna NV, SenthilkumariS.”Drug reservoir function of voriconazole impregnated human amniotic membrane: An in vitro study” Indian J Ophthalmol 2021;69:1068-72.
  3. Soundararajan Ashwinbalaji, Ravinarayanan Haribalaganesh, Subbaiah Krishnadas, Veerappan Muthukkaruppan, Srinivasan Senthilkumari “SB772077B (SB77) Alleviated the Aqueous Outflow Resistance Mediated by Cyclic Mechanical Stress in Perfused Human Cadaveric Eyes”  Sci Rep 2020;10: 10202
  4. Sara SH, Prajna NV, Senthilkumari S. Human amniotic membrane as a drug carrier An in-vitro study using fortified cefazolin ophthalmic solution. Indian J Ophthalmol. 2019 Apr;67(4):472-475.
  5. Ashwinbalaji S, Senthilkumari S, Gowripriya C, Krishnadas S, Gabelt BAT, Kaufman PL, Muthukkaruppan V. SB772077B, A New Rho Kinase Inhibitor Enhances Aqueous Humour Outflow Facility in Human Eyes. Sci Rep. 2018 Oct 19;8(1):15472.
  6. Kotnala A, Senthilkumari S, Halder N, Kumar A, Velpandian T. Microwave assisted synthesis for A2E and development of LC-ESI-MS method for quantification of ocular bisretinoids in human retina. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:10-18.
  7. Yelchuri ML, Madhavi B, Gohil N, Sajeev HS, Venkatesh Prajna N, Srinivasan S. In Vitro Evaluation of the Drug Reservoir Function of Human Amniotic Membrane Using Moxifloxacin as a Model Drug. Cornea. 2017 May;36(5):594-599.
  8. Senthilkumari S, Sharmila R, Chidambaranathan G, Vanniarajan A. Epalrestat, an Aldose Reductase Inhibitor Prevents Glucose-Induced Toxicity in Human Retinal Pigment Epithelial Cells In Vitro. J Ocul Pharmacol Ther. 2017 Jan/Feb;33(1):34-41.
  9. Senthilkumari S, Neethu M, Santhi R, Krishnadas SR, Muthukkaruppan V. Identification of glaucomatous optic nerve head changes in Indian donor eyes without clinical history. Indian J Ophthalmol. 2015 Jul;63(7):600-5.
  10. Dongare S, Sharmila R, Senthilkumari S, Gupta SK, Mathur R, Saxena R, Srivastava Genistein Alleviates High Glucose Induced Toxicity and Angiogenesis in Cultured Human RPE Cells. Int J Pharm Pharm Sci. 2015;7:294-298.
  11. Senthilkumari S, Talwar B, Dharmalingam K, Ravindran RD, Jayanthi R, Sundaresan P, Saravanan C, Young IS, Dangour AD, Fletcher AE. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. Exp Eye Res. 2014 Jul;124:24-30.
  12. Velpandian T, Arora B, Senthilkumari S, Ravi AK, Gayathri C, Azad R, Ghose S. Regional variation in the levels of macular xanthophylls and carotenoids in dietary components: comparing North and South India. J Nutr Sci Vitaminol (Tokyo). 2010;56(6):411-20.
  13. Senthilkumari S, Lalitha P, Prajna NV, Haripriya A, Nirmal J, Gupta P, Velpandian T. Single and multidose ocular kinetics and stability analysis of extemporaneous formulation of topical voriconazole in humans. Curr Eye Res. 2010 Nov;35(11):953-60.
  14. Senthilkumari S, Velpandian T, Biswas NR, Bhatnagar A, Mittal G, Ghose S. Evidencing the modulation of P-glycoprotein at blood-ocular barriers using gamma Curr Eye Res. 2009 Jan;34(1):73-7.

Awards & Recognition

  • Research Associate Fellowship, Council of Scientific & Industrial Research (CSIR), India (2006-2008)
  • International Ophthalmology Fellowship (Nov 1, 2010 – Jan 31, 2011) at Dept. of Ophthalmology & Visual Sciences, University of Wisconsin, Madison (2011)
  • DBT –CREST AWARD by the Ministry of Science & Technology, Department of Biotechnology (DBT), New Delhi (2011-2012)
  • India Alliance Welcome DBT-Intermediate Fellowship 2016 (Nov)
  • Life Member of Indian Pharmacological Society
  • Member of The Association of Research & Vision Research (ARVO) (USA)
  • Member of Indian Eye Research Group(IERG)-India ARVO Chapter
  • Recognized guide in Madurai Kamaraj University (MKU) to guide Ph.D registrants in Biotechnology
  • Recognized guide in Alagappa University to guide Ph.D registrants in Biotechnology.