Dr. P. Sundaresan

Qualification M.Sc., Ph.D.
Designation Senior Scientist
Molecular Genetics
Aravind Medical Research Foundation
e-mail id sundar@aravind.org

Introduction

Dr. P.Sundaresan received his Ph.D in Microbiology from Madurai Kamaraj University, Madurai in 1990 and served as Lecturer for two years at Birla Institute of Science and Technology, Pilani, Rajasthan, India. He then moved to the U.S and served as post-doctoral fellow at University of Pennsylvania, Philadelphia, ( 1993-1995) and Georgetown University, Washington DC (1996-1998). He worked as Research Assistant Professor at School of Medicine, Mount Sinai, New York ( 1999-2000). Dr. Sundaresan’s postdoctoral training was on structure-function of Herpes simplex virus-1 glycoprotein gE; HSV-1: Viral Gene therapy for brain and prostate cancer and making Herpes Simplex Virus-2 gB -2 recombinant viruses to study cell entry.

Dr.P.Sundaresan’s research focuses on the Molecular Genetics of eye diseases and molecular diagnosis for inherited eye diseases. His specific areas of research include molecular genetics on Aniridia, POAG, PACG,BPES, CHED, Diabetic Retinopathy; Ocular Albinism and Age related Macular Degeneration, FEVR, LHON, Congenital and Age related cataract and Identification of Biomarkers for Primary Open Angle Glaucoma.

He has published >140 scientific papers in peer reviewed national and international journals. He is a recognized Ph.D supervisor under Madurai Kamaraj University, The TamilnaduDr.M.G.R Medical University, Alagappa University and Sastra University. He has guided 18 scholars and currently 6 Research scholars are working under his guidance. He has been awarded the Biotechnology Overseas Associateship Award (2005-2006) and CREST award (2010-2011) from Ministry of Science and Technology, DBT, Govt. of India. He has received 2 ICMR awards: (1) for Biomedical Research for scientists belonging to underprivileged communities for the year 2006 and (2) for Biomedical research conducted in underdeveloped areasfor the year 2009 and also received TamilNadu Scientist award (TANSA 2013) under the discipline Biological Sciences. In addition, received Hari Om Ashram Alembic Research Award ( Medial council of India ) for 2010 from Honourable President of India at Rashtrapati Bhawan. He has received funding for research from Government of India ( ICMR, NMITLI-CSIR, DST and DBT) and Wellcome Trust.

Publications

Peer-Reviewed Journals
  1. Chen C, Yang M, Huang L, Zhao R, Sundaresan P, Zhu X, Li S, Yang Z. Whole Exome Sequencing Reveals Novel TSPAN12 Mutations in Autosomal Dominant Familial Exudative Vitreoretinopathy. Genetic testing and Molecular biomarkers 2021 Jun 2, doi: 10. 1089
  2. Viswarubhiny S, Anjanamurthy R, Vanniarajan A, Bharanidharan D, Perumalsamy V, Sundaresan P.Clinical Exome Sequencing Facilitates the Understanding of Genetic Heterogeneity in Leber Congenital Amaurosis Patients with Variable Phenotype in Southern India. Eye and Vision: 2021 6;8 (1):8:20
  3. Zhu X, Yang M, Zhao P, Li S, Zhang L, Huang L, Huang Y, Fei P, Yang Y, Zhang S, Xu H, Yuan Y, Zhang X, Zhu X, Ma S, Hao F, Sundaresan P, Zhu W, Yang Z. Catenin alpha 1 mutations cause familial exudative vitreoretinopathy by overactivatingNorrin/beta-catenin signaling . J Clin Invest. 2021 Jan 26:139869. doi: 10.1172/JCI139869. Online ahead of print. PMID:33497368.
  4. Poigaialwar Gowri, Shanmugan Mahesh Kumar, Ayyasamy Vanniarajan, Devarajan Bharanidharan, PeriasamySundaresan A hospital-based five year prospective study on the prevalence of Leber’s hereditary optic neuropathy with genetic confirmation. Molecular Vision 2020; 26:789-796.
  5. Yonova-Doing E, Zhao W, Igo RP Jr, Wang C,Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, Lee MC, Fong A, Tan AG, Khor CC, Chew EY, Hysi PG, Fan Q, Chua J, Chung J, Liao J, Colijn JM, Burdon KP, Fritsche LG, Swift MK, Hilmy MH, Chee ML, Tedja M, Bonnemaijer PWM, Gupta P, Tan QS, Li Z, Vithana EN, Ravindran RD, Chee SP, Shi Y, Liu W, Su X, Sim X, Shen Y, Wang YX, Li H, Tham YC, Teo YY, Aung T, Small KS, Mitchell P, Jonas JB, Wong TY, Fletcher AE, Klaver CCW, Klein BEK, Wang JJ, Iyengar SK, Hammond CJ, Cheng CY. Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract. Commun Biol. 2020 Dec 11:3 (1):755 doi:10 1038/s42003-020-01421-2.PMID:33311586.
  6. Hyungtaek Rim T, Ryo K, Tham YC, Kang SW, Ruamviboonsuk P, Bikbov MM, Miyake M, Hao J, Fletcher A, Sasaki M, Nangia V, Sabanayagam C, Yu M, Fujiwara K, Thapa R, Wong IY, Kayama T, Chen SJ, Kuang TM, Yamashita H, Sundaresan P, Chan JC, van Rens GHMB, Sonoda KH, Wang YX, Panda-Jonas S, Harada S, Kim R, Ganesan S, Raman R, Yamashiro K, Gilmanshin TR, Jenchitr W, Park KH, Gemmy Cheung CM, Wong TY, Wang N, Jonas JB, Chakravarthy U, Cheng CY, Yanagi Y, Saenmee A, Cao K, George R, Kazakbaeva GM, Khalimov TA, Khanna RC, Kim HW, Kulothungan V, Nangia P, Mao F, Matsuda F, Meng Q, Namba H, Pokawattana N, Oh J, Park SJ, Ravindran R, Sharma T, Shin JP, Surya J, Takahashi A, Takebayashi T, Tsujikawa A, Vashist P, Wei WB, Yang X, Yu SY, Zainullin RM, Zhao PQ. Prevalence and Pattern of Geographic Atrophy in Asia: the Asian Eye Epidemiology Consortium. Ophthalmology. 2020 Apr 25. pii: S0161-6420(20)30395-X. doi: 10.1016/j.ophtha.2020.04.019.
  7. Zhu X, Sun K, Huang L, Ma S, Hao F, Yang Z, Sundaresan P, Zhu X. Identification of Novel Mutations in the FZD4 and NDP Genes in patients with Familial Exudative Vitreoretinopathy in South India Genet Test Mol Biomarkers. 2020 Feb;24(2):92-98.
  8. Raj RK, Dhoble P, Anjanamurthy R, Chermakani P, Kumaran M, Devarajan B, Sundaresan P. Genetic characterization of Stargardt clinical phenotype in South Indian patients using sanger and targeted sequencing.Eye Vis (Lond). 2020 Jan 9;7:3.
  9. Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu X, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z. Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis. Genet Med. 2019;21:2345-2354.
  10. Ravindran RD, Sundaresan P, Krishnan T, Vashist P, Maraini G, Saravanan V, Chakravarthy U, Smeeth L, Nitsch D, Young IS, Fletcher AE. Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract. Br J Ophthalmol. 2019;103:1223-1227.
  11. Chandran P, Chermakani P, Venkataraman P, Thilagar SP, Raman GV, Sundaresan P. A novel 5 bp homozygous deletion mutation in ASPH gene associates with Traboulsi syndrome. Ophthalmic Genet. 2019;40:185-187.
  12. Berner D, Hoja U, Zenkel M, Ross JJ, Uebe S, Paoli D, Frezzotti P, Rautenbach RM, Ziskind A, Williams SE, Carmichael TR, Ramsay M, Topouzis F, Chatzikyriakidou A, Lambropoulos A, Sundaresan P, Ayub H, Akhtar F, Qamar R, Zenteno JC, Cruz-Aguilar M, Astakhov YS, Dubina M, Wiggs J, Ozaki M, Kruse FE, Aung T, Reis A, Khor CC, Pasutto F, Schlötzer-Schrehardt U. The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome. Hum Mol Genet. 2019 Apr 15. [Epub]
  13. Rajendran A, Dhoble P, Sundaresan P, Saravanan V, Vashist P, Nitsch D, Smeeth L5, Chakravarthy U, Ravindran RD, Fletcher AE. Genetic risk factors for late age-related macular degeneration in India. Br J Ophthalmol. 2018;102:1213-1217.
  14. Zhou Y, Li S, Huang L, Yang Y, Zhang L, Yang M, Liu W, Ramasamy K, Jiang Z, Sundaresan P, Zhu X, Yang Z. A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. Hum Mol Genet. 2018;27:2563-2572.
  15. Nongpiur ME, Cheng CY, Duvesh R, Vijayan S, Baskaran M, Khor CC, Allen J, Kavitha S, Venkatesh R, Goh D, Husain R, Boey PY, Quek D, Ho CL, Wong TT, Perera S, Wong TY, Krishnadas SR, Sundaresan P, Aung T, Vithana EN. Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. Ophthalmology. 2018;125:664-670.
  16. Li S, Yang M, Liu W, Liu Y, Zhang L, Yang Y, Sundaresan P, Yang Z, Zhu X. Targeted Next-Generation Sequencing Reveals Novel RP1 Mutations in Autosomal Recessive Retinitis Pigmentosa. Genet Test Mol Biomarkers. 2018;22:109-114.
  17. Raj RK, Gopalakrishnan P, Perumalsamy V, Sundaresan P. Decoding of tyrosinase leads to albinism in a nonidentical twin. J Clin Neonatol. 2018;7:59-62.
  18. Gopalakrishnan P, Haripriya A, Sundaresan P. MTHFR and MTHFD1 gene polymorphisms are not associated with pseudoexfoliation syndrome in South Indian population. Int Ophthalmol. 2018;38:599-606.
  19. Roopam D, George Puthuran, Kavitha S, Venkatesh R, Krishnadas SR, Sharmila R, Vijayakumar B, Pradeep Ramulu and Sundaresan P. Multiplex Cytokine Analysis of Aqueous Humor from the Patients with Chronic Primary Angle Closure Glaucoma. Curr Eye Res. 2017;42:1608-1613.
  20. Durga M, Prajna NV, Lumbini Devi, Sundaresan P. Genetic Analysis of CHST6 Gene in Indian Families with Macular Corneal Dystrophy. Int J Gen Sci. 2017;4:1-10.
  21. Gowthaman G, Saumi Mathews, KarthikS, Kim R, Sundaresan P. Establishment of human retinal mitoscriptome gene expression signature for diabetic retinopathy using cadaver eyes.  2017;36:150-181.
  22. Hemadevi B, Prajna NV, Srinivasan M, Sundaresan P. Genetic Perspective of Corneal Endothelial Dystrophies. JSM Genet Genomics. 2017;4:1026.
  23. Renugadevi K, Sil AK, Vijayalakshmi P, Sundaresan P. Molecular genetic analysis and diagnosis of Albinism patients in India. JSM Genet Genomics. 2017;4:1024.
  24. Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993-1004.
  25. Shah MH, Tabanera N, Krishnadas SR, Pillai MR, Bovolenta P, Sundaresan P. Identification and characterization of variants and a novel 4 bp deletion in the regulatory region of SIX6, a risk factor for primary open-angle glaucoma. Mol Genet Genomic Med. 2017;5:323-335.
  26. Yang Y, Zhang L, Li S, Zhu X, Sundaresan P. Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma. Genet Test Mol Biomarkers. 2017;21:252–8.
  27. Saikia BB, Dubey SK, Shanmugam MK, Sundaresan P. Whole mitochondrial genome analysis in South Indian patients with Leber’s hereditary optic neuropathy. Mitochondrion. 2017;36:21-28.
  28. Dangra KL, Das M, Periasamy S, Prajna NV. Bilateral Atypical Granular Corneal Dystrophy Associated with Unilateral Keratoconus in a Male Child. Middle East Afr J Ophthalmol. 2016;23:262–4.
  29. Yang Y, Yang Y, Huang L, Zhai Y, Li J, Jiang Z, et al. Whole exome sequencing identified novel CRB1 mutations in Chinese and Indian populations with autosomal recessive retinitis pigmentosa. Sci Rep. 2016;6:33681.
  30. Kader MA, Namburi P, Ramugade S, Ramakrishnan R, Krishnadas SR, Roos BR, et al. Clinical and genetic characterization of a large primary open angle glaucoma pedigree. Ophthalmic Genet. 2016;1–4.
  31. Arcot Sadagopan K, Kathirvel R, Keep RB, Sundaresan P, Huang H, Rolfs A, et al. Cutaneous freckling: Possible new clinical marker for the diagnosis of Hermansky-Pudlak syndrome in Indian Asian patients with oculocutaneous albinism. Ophthalmic Genet. 2017;38:194–6.
  32. Zhang L, Yang Y, Li S, Tai Z, Huang L, Liu Y, et al. Whole Exome Sequencing Analysis Identifies Mutations in LRP5 in Indian Families with Familial Exudative Vitreoretinopathy. Genet Test Mol Biomarkers. 2016;20:346–51.
  33. Khor CC, Do T, Jia H, Nakano M, George R, Abu-Amero K, et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016;48(5):556–62.
  34. Di Y, Huang L, Sundaresan P, Li S, Kim R, Ballav Saikia B, et al. Whole-exome Sequencing Analysis Identifies Mutations in the EYS Gene in Retinitis Pigmentosa in the Indian Population. Sci Rep. 2016;6:19432.
  35. Zhou Y, Saikia BB, Jiang Z, Zhu X, Liu Y, Huang L, et al. Whole-exome sequencing reveals a novel frameshift mutation in the FAM161A gene causing autosomal recessive retinitis pigmentosa in the Indian population. J Hum Genet. 2015;60:625–30.
  36. Burdon KP, Fogarty RD, Shen W, Abhary S, Kaidonis G, Appukuttan B, et al. Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene. Diabetologia. 2015;58:2288–97.
  37. Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, et al. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet. 2015;24:3880–92.
  38. Dubey SK, Hejtmancik JF, Krishnadas SR, Sharmila R, Haripriya A, Sundaresan P. Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in South Indian individuals with pseudoexfoliation syndrome. Curr Eye Res. 2015;40:1218–24.
  39. Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, et al. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nat Genet. 2015;47:387–92.
  40. Dubey SK, Mahalaxmi N, Vijayalakshmi P, Sundaresan P. Mutational analysis and genotype-phenotype correlations in southern Indian patients with sporadic and familial aniridia. Mol Vis. 2015;21:88–97.
  41. Neethirajan G, Krishnadas SR, Vijayalakshmi P, Shetty S, Sundaresan P. PAX6 mRNA Transcript Analysis in Various Ocular/Non-Ocular Tissues. Adv Ophthalmol Vis Syst. 2014; 1(4):00026.
  42. Sundaresan P, Simpson DA, Sambare C, Duffy S, Lechner J, Dastane A, et al. Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants. Genet Med. 2015;17:279–84.
  43. Renugadevi K, Mary JA, Perumalsamy V, Seshadri S, Jagadeesh S, Suresh B, et al. Molecular Genetic Testing for Carrier – Prenatal Diagnosis and Computational Analysis of Oculocutaneous Albinism Type 1. J Genet Disor Genet Rep 2014;3:2.
  44. Manayath GJ, Namburi P, Periasamy S, Kale JA, Narendran V, Ganesh A. A novel mutation in the NR2E3 gene associated with Goldmann-Favre syndrome and vasoproliferative tumor of the retina. Mol Vis. 2014;20:724–31.
  45. Senthilkumari S, Talwar B, Dharmalingam K, Ravindran RD, Jayanthi R, Sundaresan P, et al. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. Exp Eye Res. 2014;124:24–30.
  46. Dubey SK, Hejtmancik JF, Krishnadas SR, Sharmila R, Haripriya A, Sundaresan P. Lysyl oxidase-like 1 gene in the reversal of promoter risk allele in pseudoexfoliation syndrome. JAMA Ophthalmol. 2014;132:949–55.
  47. Duvesh R, Verma A, Venkatesh R, Kavitha S, Ramulu PY, Wojciechowski R, et al. Association study in a South Indian population supports rs1015213 as a risk factor for primary angle closure. Invest Ophthalmol Vis Sci. 2013;54:5624–8.
  48. Verma A, Perumalsamy V, Shetty S, Kulm M, Sundaresan P. Mutational screening of LCA genes emphasizing RPE65 in South Indian cohort of patients. PLoS ONE. 2013;8:e73172.
  49. Lechner J, Bae HA, Guduric-Fuchs J, Rice A, Govindarajan G, Siddiqui S, et al. Mutational analysis of MIR184 in sporadic keratoconus and myopia. Invest Ophthalmol Vis Sci. 2013;54:5266–72.
  50. Verma A, Das M, Srinivasan M, Prajna NV, Sundaresan P. Investigation of VSX1 sequence variants in South Indian patients with sporadic cases of keratoconus. BMC Res Notes. 2013;6:103.
  51. Asai-Coakwell M, March L, Dai XH, Duval M, Lopez I, French CR, et al. Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Hum Mol Genet. 2013;22:1432–42.
  52. Thanapal AT, Maple PAC, Sundaresan P, Vijayalakshmi P, Brown DWG, Jin L. Isolation and Enhanced Genetic Analysis of Rubella Virus Obtained from Infants with Congenital Ocular Defects. Curr Topic Virol. 2012;10:99-109.
  53. Sundaresan P, Vashist P, Ravindran RD, Shanker A, Nitsch D, Nonyane BAS, et al. Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. Invest Ophthalmol Vis Sci. 2012;53:7492–7.
  54. Rangachari K, Jeyalaxmi J, Eswari Pandaranayaka PJ, Prasanthi N, Sundaresan P, Krishnadas SR, et al. Significance of G-X-W motif in the myocilin olfactomedin domain. J Ocul Biol Dis Infor. 2011;4:154–8.
  55. Sundaresan P, Ravindran RD, Vashist P, Shanker A, Nitsch D, Talwar B, et al. EPHA2 polymorphisms and age-related cataract in India. PLoS ONE. 2012;7:e33001.
  56. Balasubbu S, Krishnadas SR, Jiao X, Hejtmancik JF, Sundaresan P. Evaluation of SNPs on chromosome 2p with primary open angle glaucoma in the South Indian cohort. Invest Ophthalmol Vis Sci. 2012;53:1861–4.
  57. Wang L, Wang L, He F, Bu J, Zhen Y, Liu X, et al. ABCB6 mutations cause ocular coloboma. Am J Hum Genet. 2012;90:40–8.
  58. Vilas GL, Loganathan SK, Quon A, Sundaresan P, Vithana EN, Casey J. Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations. Hum Mutat. 2012;33(2):419–28.
  59. Lalan Kumar Arya Kumar, A B, Shashikant Shetty, Vijayalakshmi, P, Sundaresan, P. Analysis of the SALL4 Gene in Patients with Duane Retraction Syndrome in a South Indian Population. Ophthalmic Genet.2011;32:156-7.
  60. Rangachari, K Dhivya, M, Eswari Pandaranayaka, P J, Prasanthi, N, Sundaresan, P, Krishnadas, R, Krishnaswamy, S. Glaucoma Database. Bioinformation. 2011;5:398-399.
  61. Rangachari, K Jeyalaxmi, J, Pandaranayaka, Eswari, Prasanthi, N, Sundaresan, P, Krishnadas, R, Krishnaswamy, S. Significance of G-X-W Motif in the Myocilin Olfactomedin Domain. J Ocul Biol Dis Infor. 2011;4:154-158.
  62. Mehta, Jodhbir Singh Hemadevi, Boomiraj, Vithana, Eranga N, Arun Kumar, Jambulingam, Srinivasan, M, Prajna, N Venkatesh, Tan, Donald T, Aung, Tin, Sundaresan, P. Absence of Phenotype-Genotype Correlation of Patients Expressing Mutations in the SLC4A11 Gene. Cornea. 2010;29:302-306.
  63. Hemadevi, Boomiraj Srinivasan, M, Arun Kumar, Jambulingam, Prajna, N Venkatesh, Sundaresan, P. Genetic Analysis of Patients with Fuchs Endothelial Corneal Dystrophy in India. BMC Ophthalmol. 2010;10.
  64. Ye, M Berry-Wynne, K M, Asai-Coakwell,M, Sundaresan, P, Footz, T, French, C R, Abitbol, M, Fleisch, V C, Corbett, N, Allison, W T, Drummond, G, Walter, M A, Underhill, T M, Waskiewicz, A J, Lehmann, OJ. Mutation of the Bone Morphogenetic Protein GDF3 causes Ocular and Skeletal Anomalies. Hum Mol Genet. 2010;19:287-298.
  65. Renugadevi, K Asim Kumar Sil, Vijayalakshmi, P, Sundaresan, P. Spectrum of Candidate Gene Mutations Associated with Indian Familial Oculocutaneous and Ocular Albinism. Mol Vis. 2010;16:1514-1524.
  66. Sundaresan, P Mahesh Kumar, Thompson, S, Fingert, J H. Reduced Frequency of Known Mutations in a Cohort of LHON Patients from India. Ophthalmic Genetics. 2010;31:196-199
  67. Suganthalakshmi, Balasubbu Sundaresan, P, Anand Rajendran, Kim, R, Govindarajan, G, Namperumalsamy, P, Hejtmancik, J F. Association Analysis of Nine Candidate Gene Polymorphisms in Indian Patients with Type 2 Diabetic Retinopathy. BMC Med Genet. 2010;11:158.
  68. Eswari Pandaranayaka, P J Prasanthi, N, Kannabiran, N, Rangachari, K, Dhivya, M, Krishnadas, R, Sundaresan, P, Krishnaswamy, S. Polymorphisms in an Intronic Region of the Myocilin Gene Associated with Primary Open-Angle Glaucoma – A Possible Role for Alternate Splicing. Mol Vis. 2010;16:2891-2902.
  69. Ye, M Berry-Wynne, K M, Asai-Coakwell, M, Sundaresan, P, Footz, T, French, C R, Abitbol, M, Fleisch, V C, Corbett, N, Allison, W T, Drummond, G, Walter, M A, Underhill, T M, Waskiewicz, A J, Lehmann, O J. Mutation of the Bone Morphogenetic Protein GDF3 causes Ocular and Skeletal Anomalies. Hum Mol Genet. 2010;19:287-98
  70. Asai-Coakwell, Mika French, Curtis R, Ye, Ming, Garcha, Kamal, Bigot, Karin, Perera, Anoja G, Staehling-Hampton, Karen, Mema, Silvina C, Chanda, Bhaskar, Mushegian, Arcady, Bamforth, Steven, Doschak, Michael R, Li, Guang, Dobbs, Matthew B, Giampietro, Philip F, Brooks, Brian P, Vijayalakshmi, P, Sauve, Yves, Abitbol, Marc, Sundaresan, P, Van Heyningen, Veronica, Pourquie, Olivier, Underhill, T Michael, Waskiewicz, Andrew J, Lehmann, Ordan J.Incomplete Penetrance and Phenotypic Variability Characterize Gdf6-Attributable Oculo-Skeletal Phenotypes. Hum Mol Genet. 2009;18:1110-1121.
  71. Sundaresan, P Vijayalakshmi, P, Thompson, Stewart, Ko, Audrey C, Fingert, John H, Stone, Edwin M.Mutations that are a Common cause of Leber Congenital Amaurosis in Northern America are Rare in Southern India. Mol Vis. 2009;15:1781-1787.
  72. Renugadevi, K Sil, A K, Vijayalakshmi, P, Sundaresan, P. Novel Human Pathological Mutations Gene Symbol:OCA2 Disease Albinism, Oculocutaneous II. Hum Genet. 2009;125:340.
  73. Neethirajan, Guruswamy Solomon, Abraham, Krishnadas, R, Vijayalakshmi, P, Sundaresan, P.Genotype, Phenotype Association in Indian Congenital Aniridia. Indian J Pediatr. 2009;76:513-517.
  74. Amala Rajasundari, T Sundaresan, P, Vijayalakshmi, P, Brown, D W, Jin, L, Jitendra Jethani.Laboratory confirmation of congenital rubella syndrome in infants: an eye hospital based investigation. J Med Virol. 2008;80:536-546.
  75. Hemadevi, Boomiraj Veitia, R A, Srinivasan, M, Arun Kumar, Jambulingam, Prajna, N Venkatesh, Lesaffre, C, Sundaresan, P. Identification of Mutations in the SLC4A11 Gene in Pateients with Recessive Congenital Hereditary Endothelial Dystrophy. Arch Ophthal. 2008;126:700-708.
  76. Nallathambi, J Lessaffre, Corinne, Moumne, Lara, Padaranayaka, Eswari, Usha, Kim R, Krishnaswamy, S, Sundaresan, P, Veita, Reiner A. Differential Functional Effects of Novel Mutations of the Transcription Factor FOXL2 in BPES Patients. Hum Mutat. 2008;29:123-130.
  77. Ramya Devi, Ramachandran Yao, Wenliang, Vijayalakshmi, P, Sergeev, Yari V, Sundaresan, J, Heijtmanch, F. Crystallin Gene Mutations in Indian Falilies with Inherited Pediatric Cataract. Mol Vis. 2008;14:1157-1169.
  78. Eswari Pandaranayaka, P J Kanagavalli, Janakaraj, Krishnadas, R, Sundaresan, P, Krishnasamy, S. Over Expression and Purification of Recombinant Human Myocilin. World J Microbiol Biotechnol. 2008;24:903.
  79. Moumne, L Batista, F, Benayoun, B A, Nallathambi, J, Fellous, M, Sundaresan, P, Veitia, R A. The Mutations and Potential Targets of the forhead Transcription Factor FOXL2. Molecular and Cellular Endocrinology. 2008;282:2-11.
  80. Hewitt, Alex W Samples, John R, Allingham, R Rand, Jarvela, Irma, Kitsos, George, Krishnadas, R, Richards, Julia E, Lichter, Paul R, Petersen, Michael B, Sundaresan, P, Wiggs, Janey L, Mackey, David A, Wirtz, Mary K. Investigation of Founder Effects for the Thr377Met Myocilin Mutation in Glaucoma Families from Differing Ethnic Backgrounds. Mol Vis. 2007;13:487-492.
  81. Nallathambi, J Moumne, L, De Baere E, Beysen, E, Usha, Kim R, Sundaresan, P, Veitia, R A. A Novel polyalanine Expansion in FOXL2: the Forst Evidence for a recessive form of the Blepharophimosis Syndrome (BPES) associated with Ovarian Dysfunction. Hum Genet. 2007;121:107-112.
  82. Shukla, Dhananjay Anand Rajendran, Gibbs, Daniel, Suganthalakshmi, Balasubbu, Zhang, Kang, Sundaresen, P. Unusual Manifestations of X-Linked Retinoschisis: Clinical Profile and Diagnostic Evaluation. Am. J. Ophthalmol. 2007;144:419-423.
  83. Nallathambi, J Neethirajan, Guruswamy, Usha, Kim R, Jitendra Jethani, Sundaresan, P. FOXL2 mutaions in Indian Families with Bleparophimosis-ptosis-epicanthus inversus Syndrome. J Genetics. 2007;86:165-168.
  84. Suganthalakshmi, Balasubbu Anand Rajendran, Kim, R, Namperumalsamy, P, Sundaresan, P. Emerging Patterns of Possible Potential Candidate Gene Polymorphisms Associated with Diabetic Retinopathy – A Review. Asian J Exp Sci. 2006;20:15-28.
  85. Nallathambi, J Neethirajan, Guruswamy, Shashikant Shetty, Vijayalakshmi, P, Sundaresan, P. PAX6 Missense Mutations Associated in Patients with Optic Nerve Malformation. Mol Vis. 2006;12:236-242.
  86. Suganthalakshmi, Balasubbu Anand Rajendran, Kim, R, Mahalakshmi, Rajendran, Karthik Prakash, Namperumalsamy, P, Sundaresan, P. Association of VEGF and eNOS Gene Polymorphisms in Type 2 Diabetic Retinopathy. Mol Vis. 2006;12:336-341.
  87. Neethirajan, Guruswamy Nallathambi, J, Krishnadas, R, Vijayalakshmi, P, Shashikant Shetty, Collinson, Jon Martin, Sundaresan, P. Identification of Novel Mutant PAX6 Alleles in Indian Cases of Familial Aniridia. BMC Ophthalmol. 2006;6.
  88. Nallathambi, J Shukla, Dhananjay, Anand Rajendran, Namperumalsamy, P, Muthulakshmi, R, Sundaresan, P. Identification of Novel FZD4 Mutations in Indian Patients with Familial Exudative Vitreoretinopathy. Mol Vis. 2006;12:1086-1092.
  89. Suganthalakshmi, Balasubbu Anand Rajendran, Shukla, Dhananjay, Kim, R, Nallathambi, J, Sundaresan, P. Genetic variations in the hotspot region of RSI Gene in Indian patients with Juvenile X-Linked retinoschisis. Mol Vis. 2006;19:611-617.
  90. Neethirajan, Guruswamy Krishnadas, R, Vijayalakshmi, P, Shashikant Shetty, Sundaresan, P. PAX6 Gene Variations Associated with Aniridia in South India. BMC Med Genet. 2004;5:9-15.
  91. Sundaresan, P Asim Kumar Sil, Philp, Alisdair R, Randolph, Mary A, Natchiar, G, Namperumalsamy, P.Genetic Analysis of Oculocutaneous Albinism Type 1 (OCA1) in Indian Families: two novel frameshift mutations in the TYR gene. Mol Vis. 2004;10:1005-1010.
  92. Neethirajan, Guruswamy Collinson, J Martin, Krishnadas, R, Vijayalakshmi, P, Shashikant Shetty, Reena, Chandrashekhar, Sundaresan, P. De Novo Deletions in the Paired Domain of PAX6 in South Indian Aniridic Patients. J Human Genet. 2004;49:647-649.
  93. Kanagavalli J, Krishnadas SR, Eswari  J., Krishnaswamy S , Sundaresan P Evaluation and understanding of myocilin mutations in Indian primary open angle glaucoma patients.  Molecular Vision 2003 9  606-614.
  94. Neethirajan P, Hanson I M,  Krishnadas SR , Vijayalakshmi P, Anupkumar K,       Sundaresan P.  A novel PAX6 gene mutation in an Indian Aniridia patient. Molecular Vision 2003  9 205-209.
  95. Kanagavalli, Janakaraj Pandaranayaka, Eswari, Krishnadas, R, Krishnaswamy, Sankaran, Sundaresan, P. Current Ophthalmology: A Review of Genetic and Structural Understanding of the Role of Myocilin in Primary Open Angle Glaucoma. Indian J Ophthalmol. 2004;52:271-280.
  96. .Sundaresan P, Hunter WD, Martuza RL, Rabkin SD. Attenuated,replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice. J Virol. 2000 Apr;74(8):3832-41.
  97. Todo T, Rabkin SD, Sundaresan P, Wu A, Meehan KR, Herscowitz HB, Martuza RL. Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus. Hum Gene Ther. 1999 Nov 20;10(17):2741-55.
  98. Chahlavi A, Rabkin S, Todo T, Sundaresan P, Martuza R. Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice. Gene Ther. 1999 Oct;6(10):1751-8. PubMed PMID: 10516725.
  99. Miyatake SI, Tani S, Feigenbaum F, Sundaresan P, Toda H, Narumi O, Kikuchi H, Hashimoto N, Hangai M, Martuza RL, Rabkin SD. Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo.  Gene Ther. 1999 Apr;6(4):564-72
  100. Walker JR, McGeagh KG, Sundaresan P, Jorgensen TJ, Rabkin SD, Martuza RL.Local and systemic therapy of human prostate adenocarcinoma with the conditionally replicating herpes simplex virus vector G207. Hum Gene Ther. 1999 Sep 1;10(13):2237-43.
  101. Nagashunmugam T, Lubinski J, Wang L, Goldstein LT, Weeks BS, Sundaresan P, Kang EH, Dubin G, Friedman HM. In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor. J Virol. 1998 Jul;72(7):5351-9.
  102. Weeks BS, Sundaresan P, Nagashunmugam T, Kang E, Friedman HM. The herpes simplex virus-1 glycoprotein E (gE) mediates IgG binding and cell-to-cell spread  through distinct gE domains. Biochem Biophys Res Commun. 1997 Jun 9;235(1):31-5.
  103. Sundaresan P; Raja NU; Gunasekaran P.Induction and accumulation of phytoalexins in cowpea roots infected with a mycorrhizal fungus Glomus fasciculatum and their resistance to fusarium with disease Journal of Biosciences. 1993 Jun; 18(2): 291-301
  104. Raja NU, Sundaresan P, Gunasekaran P, Lakshmanan M. Involvement of Arbuscules and Phosphates in P uptake During VA mycorrhizal Symbiosis.  Indian J. Microbiol.  1989 29  303-311.
  105. . Sundaresan P, Raja NU, Gunasekaran P,  Lakshmanan M   Studies on Nitrate Reduction by VAM fungal spores,   Current Science 1988 57  84-85.
  106. Sundaresan P, Raja NU, Gunasekaran P, Lakshmanan M. Response of Two VA Mycorrhizal Fungi on Vigna unguiculataWalp. J.Swamy Bot. Club 1987 491  33-37.
  107. Gunasekaran P,  Sundaresan P,  Raja NU and Lakshmanan M. Effect of pH, Temperature and Nutrients on the germination of a VAM fungus Glomus fasciculatum in  vitro, Proc. Indian Acad. Sci. (Plant Science) 1987 97  231-234.
Book Chapters:
  1. Prasanthi N, Rangachari S.R.Krishnadas, P.Sundaresan, Diagnosis and Management of Glaucoma: Chapter – 4- Genetics of Glaucoma and its future JAYPEE HIGNLIGHTS, Medical Publishers Inc. page no.18-30
  2. Sharola Dharmaraj, Anshuman Verma , Sundaresan Periasamy and Chitra Kannabiran 2019.Leber Congenital Amaurosis in Asia: Genetic Eye Research in Asia and the Pacific. Advances in Vision Research, Volume II ( Springer Link, Editors: Gyan  Prakash and Takeshi Iwata) Pages: 191-231.
  3. Roopam Duvesh, , R Venkatesh, S Kavitha, , Pradeep Ramulu, SR Krishnadas, and P Sundaresan.  Genetic Complexity of Primary Angle Closure Glaucoma in Asians: Genetic Eye Research in Asia  .  Advances in Vision Research Volume 1 ( Springer Link, Editors: Gyan  Prakash and Takeshi Iwata) pages: 291-313.
  4. Prakadeeswari Gopalakrishnan, Aravind Haripriya , Banushree Ratukondla, Sundaresan Periasamy. 2019. Genetics of Exfolilation Syndrome in Asians: Genetic Eye Research in Asia and the Pacific. Advances in Vision Research, Volume II ( Springer Link, Editors: Gyan  Prakash and Takeshi Iwata) Pages: 381-391.
  5. Bharanidharam Devarajan, Ayyasamy Vanniarajan , Sundaresan Periasamy. Genomic Approaches of Eye diseases: An Asian Perspective: Genetic Eye Research in Asia and the Pacific. Advances in Vision Research, Volume II (Springer Link, Editors: Gyan  Prakash and Takeshi Iwata) Pages403-415
  6. Durga Murugan, Sindhura Devi Adsumilli, Namperumalsamy Venkatesh Prajna Periasamy Sundaresan 2021. Molecular Genetics and Clinical Aspects of Macular Corneal Dystrophy. Advances in Vision Research, Volume III. Genetic Eye Research around the Globe. (Springer Link, Editors: Gyan Prakash and Takeshi   Iwata) Pages 289-302.
 Articles published in conferences
  1. P. Gunasekaran, N.Ubalthoose Raja, P.Sundaresan and M.Lakshmanan.  Extraction of DNA from Glomus etunicatum.  Proceedings of the First Asian Conference on Mycorrhizae. 1989  309-310.
  2. Dr.P.Sundaresan, N.Ubalthoose Raja, P.Gunasekaran, M.Lakshmanan (1988). Mycorrhizal Association in Cowpea (Vigna unguiculata) Incareases Phosphate Uptake Under Water  Stress Condition. Mycorrhizal Round Table Proceedings of  Workshop Held in New Delhi 13-15 March 1987: 461-470.
  3. N. Ubathoose Raja, P. Sundaresan, P. Gunasekaran, M. Lakshmanan, (1988). Improved Growth of Cowpea by Various Isolates of VA Mycorrhizal Fungi. Mycorrhizal Round Table Proceedings of Workshop Held in New Delhi 13-15 March 1987 313-321.
  4. M. Lakshmanan, N.Ubalthoose Raja, P.Gunasekaran, P.Sundaresan (1988). Production of Phytoalexin in Cowpea Infected with VA Mycorrhizal Fungi. Mycorrhizal Round Table Proceedings of Workshop Held in New Delhi 13-15 March 1987:530-534.
  5. P.Gunasekaran, P.Sundaresan, N.Ubalthoose Raja and M.Lakshmanan (1988). Toxic Effects of Some Agricultural Fungicides on the Mycorrhizal Association of Cowpea.  Mycorrhizal Round Table Proceedings of Workshop Held in New Delhi 13-15 March 1987: 550-559.
Non-Peer Reviewed Journals
  1. Anshuman Verma, Sundaresan P, Karthikeyan AS, Vijayalakshmi P. Gene Therapy for ‘Leber Congenital Amaurosis’ Brings a Hope to Cure Inherited Childhood Blindness. TNOA. 2013;52:83-89
  2. Suganthalakshmi B, Rajendran A, Kim R, Namperumalsamy P Sundaresan P. Emerging Patterns of Possible Potential Candidate Gene Polymorphisms Associated with Diabetic Retinopathy-a Review. Asian J. Exp. Sci., 2006 Vol. 20, Supplement, 15-28.

Awards & Recognition

2017: Hari Om Ashram Alembic Research Award for 2010 from Medical Council of India – Received from our Honourable President at Rashtrapati Bhavan, New Delhi

2015: Tamil Nadu Scientist Award (TANSA 2013) – Under the discipline – Biological Sciences

2013: ICMR AWARD and Prize: For Biomedical Research conducted in Underdeveloped Areas for the year 2009

2011: DBT CREST Award, Government of India

2009: ICMR AWARD and Prize: For Biomedical Research for scientists belonging to underprivileged communities for the year 2006